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Table 2 Functional properties of CD8+ lymphocytes in individuals with pleural plaque and patients with malignant mesothelioma

From: Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes

Parameters HV PP MM
CD3+CD8+ (%) + + +
CD107a+ (%) + + +
IFN-γ+ (%) + + +
Granzyme B+ (%) Before + + +
After + ++ +
After-Before + ++ +
Perforin+ (%) Before ++ +++ +++
After ++ +++ ++
After-Before ++ ++ +
CD45RA- (%) + ++ ++
CD3+CD8+ (cell number) ++ + +
  1. HV healthy volunteers, PP asbestos-exposed individuals with pleural plaque, MM asbestos-exposed patients with malignant mesothelioma, Before the percentage of granzyme B+ cells in fresh CD8+ lymphocytes, After the percentage of granzyme B+ cells in stimulated CD8+ lymphocytes, After-Before the percentage of granzyme B+ or perforin+ cells in fresh CD8+ lymphocytes was subtracted from the percentage of granzyme B+ or perforin+ cells in stimulated cells
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Environmental Health and Preventive Medicine

ISSN: 1347-4715

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