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|
group
|
BMDL10
|
LOAEL
|
|---|
|
uterus/body weight ratio (g/kg, %)
|
F Value
|
P-Value
|
uterus/body weight ratio (g/kg, %)
|
F Value
|
P-Value
|
|---|
|
Variance source
|
|
Blank control
|
0.79 ± 0.08
|
–
|
–
|
0.79 ± 0.08
|
–
|
–
|
|
vehicle control
|
0.75 ± 0.14
|
–
|
–
|
0.75 ± 0.14
|
–
|
–
|
|
Main effect
|
|
BPA
|
0.80 ± 0.20
|
3.65
|
0.06
|
0.95 ± 0.23
|
11.87
|
P < 0.05
|
|
NP
|
0.79 ± 0.22
|
1.00
|
0.32
|
0.93 ± 0.18
|
1.71
|
0.20
|
|
DES
|
0.85 ± 0.19
|
0.72
|
0.40
|
0.93 ± 0.16
|
5.57
|
P < 0.05
|
|
Interaction
|
|
BPA + NP
|
0.95 ± 0.27
|
1.07
|
0.31
|
1.00 ± 0.19
|
1.09
|
0.30
|
|
BPA + DES
|
0.87 ± 0.21
|
0.12
|
0.73
|
1.08 ± 0.25
|
0.003
|
0.96
|
|
NP + DES
|
0.80 ± 0.17
|
1.07
|
0.31
|
0.93 ± 0.12
|
2.69
|
0.11
|
|
BPA + NP + DES
|
0.92 ± 0.23
|
0.01
|
0.911
|
1.06 ± 0.11
|
0.49
|
0.49
|
- ANOVA was used to test the statistical significance for the main effect and interaction. “P < 0.05” indicated statistically significant main effect for individula EDCs or interactions among EDCs
- BPA Bisphenol A; NP Nonylphenol, DES Diethylstilbestrol, BMDL Benchmark dose lower confidence limit,LOAEL Lowest observed adverse effect level